TOLFENAMIC ACID

TOLFENAMIC ACID - Names and Identifiers

Name	tolfenamic acid
Synonyms	CLOTAM gea6414 TOLFENAMIC ACID tolfenamic acid LABOTEST-BB LT00772313 2-(3-CHLORO-O-TOLUIDINO)BENZOIC ACID 2 (3-CHLORO-2-METHYLANILINO)BENZOIC ACID N-(3-Chloro-ortho-tolyl) anthranilic acid n-(2-methyl-3-chlorophenyl)anthranilicacid 2-((3-chloro-2-methylphenyl)amino)-benzoicaci 2-[(4-chloro-3-methylphenyl)amino]benzoic acid 2-[(3-CHLORO-2-METHYLPHENYL)AMINO]BENZOIC ACID 1,2-Distearoyl-sn-glycero-3-phosphocholine, DSPC
CAS	13710-19-5
EINECS	237-264-3
InChI	InChI=1/C14H12ClNO2/c1-9-11(15)6-4-8-12(9)16-13-7-3-2-5-10(13)14(17)18/h2-8,16H,1H3,(H,17,18)
InChIKey	YEZNLOUZAIOMLT-UHFFFAOYSA-N

TOLFENAMIC ACID - Physico-chemical Properties

Molecular Formula	C14H12ClNO2
Molar Mass	261.7
Density	1.2037 (rough estimate)
Melting Point	210-214°C
Boling Point	405.4±40.0 °C(Predicted)
Flash Point	199°C
Water Solubility	Soluble in water (slightly), acetone (~10 mg/ml), DMSO (52 mg/ml at 25°C), methanol (~10 mg/ml) and ethanol (50 mg/ml).
Solubility	Practically insoluble in water, soluble in dimethylformamide, sparingly soluble in ethanol and in methylene chloride. It dissolves in dilute solutions of alkali hydroxides.
Vapor Presure	2.66E-07mmHg at 25°C
Appearance	White crystalline powder
Color	White to Off-White
Merck	14,9513
pKa	3.66±0.36(Predicted)
Storage Condition	2-8°C
Refractive Index	1.5270 (estimate)
MDL	MFCD00133865
Use	For the synthesis of non-steroidal anti-inflammatory and analgesic drugs

TOLFENAMIC ACID - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	22 - Harmful if swallowed
UN IDs	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	CB2687500
HS Code	29224919
Hazard Class	6.1
Packing Group	III

TOLFENAMIC ACID - Reference Information

EPA chemical information	Information provided by: ofmpub.epa.gov (external link)
overview	tromethic acid is a non-steroidal anti-inflammatory drug, which is a kind of antipyretic, analgesic and anti-inflammatory drug widely used in clinic. tromethic acid (Tolfenamicacid), an o-aminobenzoic acid derivative developed by GEA Company of Denmark.
characteristics	the anthranilic acid derivative (Tolfenamicacid) developed by Danish GEA company has an IC50 of 15.0 for inhibiting cyclooxygenase COX-1/COX-2, indicating that tromethic acid has strong selectivity to COX-2, so it has strong anti-inflammatory and analgesic effects and less side effects.
application	trophate plays an antipyretic and analgesic effect by inhibiting the production of cyclooxygenase. at present, it is mainly used in the treatment of rheumatoid arthritis, migraine and other diseases clinically. in recent years, scholars at home and abroad have conducted various researches on this, it is found that trophate also plays an important role in inhibiting the growth of tumor cells, inducing tumor cell apoptosis, interfering with tumor cell signal transduction, regulating the activity of proto-oncogenes and tumor suppressor genes, and inhibiting tumor angiogenesis. It also plays an important role in bladder adenocarcinoma, esophageal cancer, Colorectal cancer, prostate cancer, lung cancer, breast cancer, ovarian cancer, thyroid cancer, neuroblastoma, rhabdomyosarcoma, head and neck tumors and other tumor cells have shown inhibitory effects, it has shown potential clinical application prospects in the field of anti-tumor.
biological activity	Tolfenamic Acid is a COX-2 inhibitor with IC50 of 0.2 μM.
Target	Value
COX-2	0.2 μM
use	for synthetic non-steroidal anti-inflammatory analgesics

Last Update：2024-04-10 22:29:15

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TOLFENAMIC ACID

tolfenamic acid

CAS: 13710-19-5

Molecular Formula: C14H12ClNO2

TOLFENAMIC ACID - Names and Identifiers

TOLFENAMIC ACID - Physico-chemical Properties

TOLFENAMIC ACID - Risk and Safety

TOLFENAMIC ACID - Reference Information

Supplier List

TOLFENAMIC ACID Request for Quotation

tolfenamic acid

CAS: 13710-19-5

Molecular Formula: C14H12ClNO2

TOLFENAMIC ACID - Names and Identifiers

TOLFENAMIC ACID - Physico-chemical Properties

TOLFENAMIC ACID - Risk and Safety

TOLFENAMIC ACID - Reference Information

Supplier List

TOLFENAMIC ACID